In our recent Science paper we described a new surgical adhesive based on alpha-lipoic acid (aLA). Like a superglue, the adhesive bonds rapidly upon contact with wet tissue through in-situ aLA polymerization. This adhesive can be formulated as a sprayable or brushable liquid, an elastomeric patch, or a powder. Numerous surgical uses are envisioned, as the physical properties and biodegradation rate can be fine-tuned by monomer composition. One potential clinical application for the new adhesive is for sealing amniotic sac punctures created during fetal surgery. These punctures predispose the patient to preterm delivery, increasing the risk of fetal mortality and morbidity. An effective fetal membrane sealant could prolong gestation, decreasing these risks and reducing healthcare costs. As a step toward this goal, we used a mouse model of fetal membrane sealing to show that the ad
hesive increased fetal survival from 0% to 100%.
New Biodegradable Adhesive Seals Fetal Membrane Punctures and Increases Fetal Survival
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